Recent Advances, Controversies, and Emerging Trends in MBC
Over the last 20 years, advances in HER2 targeting treatments, antibody-drug conjugates (ADCs), immune checkpoint inhibitors (ICIs), and cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have prolonged survival and changed the breast cancer treatment landscape. Success leads to more questions about optimal drug sequencing, mechanisms of resistance, and how to overcome that resistance. Let’s ask Dr. Stephanie Graff to help us tackle these topics and more.
2022 in Review: Best in MBC with Dr. Erika Hamilton
Welcome to the first Road to A Cure episode of Season 6. Our guest is the incomparable Dr. Erika Hamilton, a breast oncologist and researcher who, as she says herself, doesn’t shy away from difficult questions. In this episode, we get a review—subtype by subtype—of the biggest news over the past 15 months. Of course, we also talk about what is on the horizon in MBC.
Dr. Nancy Lin: Are CNS Mets Becoming More Treatable? What’s New with STOP-HER2?
Brain metastases are unfortunately an all too common and devastating complication of breast cancer. The blood-brain barrier has long been a key obstacle to developing effective systemic therapies; however, newer agents are showing signs of overcoming this challenge. Dr. Nancy Lin explains.
ER Progression and Resistance: Causes, Consequences, and Hope
Endocrine therapy is an effective way to treat hormone-sensitive breast cancers, but de novo and acquired resistance to this treatment remains a major challenge. In this episode, the Our MBC Life team hears from two dynamic MSK oncologists Dr. Pedram Razavi and Dr. Komal Jhaveri on treatment strategies and the latest research around the problem of endocrine resistance.
Dr. Stephanie Graff: Understanding Progression
What does it mean when our cancer shows progression? And how do we know when that happens? The Our MBC Life team gets the lowdown from Dr. Stephanie L. Graff.
Dr. Priya Kumthekar: Glimpses of Hope for Leptomeningeal Metastases
Co-hosts Victoria Goldberg and Dr. Paula Jayne sit down with neuro-oncologist Dr. Priya Kumthekar to talk about leptomeningeal metastases: what they are, how are they treated, and what research is upcoming, including a discussion on ANGled, the new Phase 3 trial for MBC patients newly diagnosed with leptomeningeal metastases.
Dr. Timothy Pluard: the Future of MBC Care is Already Here
The future of personalized care for those living with MBC is already here, and it is happening in Kansas City, Missouri. Dr. Timothy Pluard, Medical Director of the Kansas City’s Saint Luke’s Koontz Center for Advanced Breast Cancer is with us today and we’ll ask him how he and his team create an individualized, completely comprehensive plan for each woman.
MBC101 - what happens when MBC spreads to the brain?
On 10/12/21 Lianne Kraemer, an MBC patient advocate living with brain mets , and SHARE hosted two brilliant young clinicians from Moffitt in a discussion on management of breast cancer brain metastases. Today we are bringing you this webinar with our additional commentary. We will let you in on a little secret. This episode is a glimpse into how we envision the next season’s Road to a Cure. It will include more content with an educational angle for the newly diagnosed or those who are ready to take a deeper dive with us into the basics. We call it MBC101.
Road to a Cure - drug resistance
It is fitting that our 7th and last stop before the SABCS is back to NYC. Co-hosts Lisa Laudico and Ellen Landsberger talk with Dr Sarat Chandarlapaty, a leading Physician Scientist at MSKCC. As both a physician treating patients and a scientist in the lab, Dr. Chandarlapaty gives us an understanding of translational medicine, transferring what he learns from his patients back into the lab to answer questions that advance the treatment of metastatic breast cancer.
Road to a Cure - ABC with Dr. Fatima Cardoso
This is the sixth stop in our series Road to a Cure. From the start our goal for this series was not only to educate and give hope to every listener but also to ensure that each of these special interviews feels like an intimate conversation with our smartest friend who also happens to be an oncologist researcher. This episode will not disappoint., Co-hosts Victoria Goldberg and Lisa Laudico, sit down with the Director of the Breast Unit of the Champalimaud Clinical Center in Lisbon, Portugal, Dr. Fatima Cardoso.
Road to a Cure - use of immunotherapy
This week we are visiting Dr Stephanie Goff at the NIH in Bethesda, Maryland. Dr Goff is a surgical oncologist and a senior member of a research team led by Dr. Steven A. Rosenberg, a man widely regarded as the father of immunotherapy. A friend, who knows a thing or two about this place. is joining us on this trip. Her name is Judy Perkins, and she is the first MBC patient who has been cured by a revolutionary immunotherapy treatment, known as adoptive cell therapy, that was administered by Dr Goff and her colleagues at the NCI.
Road to a Cure - Dr. Heather Parsons & Dr. Nancy Lin
The Road to a Cure series heads to Boston to have Senior Producer and Co-host, Victoria Goldberg and co-host Dr. Paula Jayne speak with Dr. Nancy Lin and Dr. Heather Parsons about the possibilities and the current barriers to considering a cure for HER2+ MBC. Dr. Parsons and Dr. Lin are medical oncologists and professors at Harvard Medical School. Dr. Lin is also the Director of the Metastatic Breast Cancer Program and the Associate Chief of the Division of Breast Oncology at Dana Farber Cancer Institute. While an amazing gift, long-term survival among some HER2+ patients can also sometimes bring special challenges. Given the higher prevalence of brain metastases among HER2+ patients, Drs. Lin and Parsons also discuss current research on brain mets, along with areas of promising overall MBC research for each subtype.
Road to a Cure - Dr. Sara Hurvitz
The Road to a Cure series gets on the redeye to LA to have Senior Producer and Co-host, Victoria Goldberg and co-host Kate Pfitzer speak with Dr. Sara Hurvitz. She talks about her perspective on where we are as we work for a cure, the HER2+ studies she is excited about, and other research that is intriguing as it relates to all subtypes
Road to a Cure - Dr. Larry Norton
Our special series, Road to a Cure, makes its first stop at Memorial Sloan Kettering Cancer Center in New York, with an interview with Dr. Larry Norton. He is Senior Vice President in the Office of the President, and Deputy Director for Clinical and Translational Science in the Memorial Sloan Kettering Cancer Center. Dr. Norton’s also the Medical Director of the Evelyn H. Lauder Breast Center at MSK and a founder of the Breast Cancer Research Foundation. Senior Producer & Host Lisa Laudico and co-host Dr. Ellen Landsberger speak with Dr. Norton on what he sees happening with Metastatic Breast Cancer research today. They ask him about what lines of research are most exciting to him and also all about how he cares for his own mental health
Report Back from ASCO: What’s the Latest in Metastatic Breast Cancer
Are you living with ER+/HER2- or TNBC MBC and tired of hearing about new HER2 therapies and wondering when it will be your turn? Just after the meeting SHARE welcomed Dr. Timothy Pluard from University of Missouri-KC School of Medicine to a webinar highlighting promising data from trials and labs across the globe presented at the this year’s meeting,
The Magic of Palliative Care: Our Stories
Want to know why we call it “magic?” Hear from people living with MBC about their experiences. While they all agree and encourage others to seek Palliative Care they also are aware of the barriers to access. Our guests cover it all. And it gets real.
Introducing the BECOME Project & Survey
The MBC Alliance asks the question “How can we ensure Black people are better represented in cancer research? Finding the answer starts with patient voices.” The BECOME Project is positioned to do just that. BECOME project lead Stephanie Walker and committee member Sheila Fuhs join Lisa Laudico to talk about the important initiative and how YOU can get involved.
Clinical Trials: The Patient Perspective Part 2
We know the challenges of trials and the barriers to recruitment as outlined in part 1. Now in Part 2 we explore solutions with patient advocates and medical professionals who are working to find ways forward. Clinical Trials from a Patient Perspective Part II. Let’s solve this.
Clinical Trials: The Patient Perspective Part 1
What’s it like to try and find a trial as a patient? What are the challenges and hurdles that have to be overcome? How do we get to a better place? In this episode we hear the perspective of patients and then go to the experts to get some answers. Part 1 of a 2 part series on Clinical Trials.